Without application of IPSec, any attacks utilizing Man-in-the-middle techniques will have the same likelihood in IPv6 as in IPv4.

If we keep in mind that IPSec is strongly linked to IPv6, its usage alone would be enough to avoid any problems regarding connection hijacking attempts. Unfortunately, the dominant practice we see today in terms of IPv6 deployment already in place is that network operators do not make any use of IPSec. The use of certificates can also provide the needed end-to-end authentication at the application level (e.g. Web servers). Without such end-to-end security mechanisms, a man-in-the-middle hijack is a possibility.